RIKEN-Max Planck Joint Research Center for commitment Chemical Biology and a number of other establish have recognized a sugar substances that lower the inflammatory response and progression of emphysema, a most common integral of chronic obstructive pulmonary disease (COPD). According to Naoyuki Taniguchi, the chief of the classification, this the action or process of discovering or being discovered could lead to the development of drugs based on glycans—biological sugar molecules—for the treatment of diseases such as COPD, which is the fourth leading cause of death worldwide.
They are surprised if this contraction might be integrated with the vandalization that smoking causes to the lung. Taniguchi says, “We are not exactly sure of the mechanism through which smoking leads us to a reduction and decrease in keratan sulfate, but felt that clearly the reduction is important in philosophy about glycan-based strategies and philosophies for confront emphysema and COPD.”
one a model of emphysema triggered by the enzyme elastase, and the other an exacerbation of smoking-induced emphysema triggered by LPS, a toxin found in bacterial cell walls.In the first model, they found that that treatment with L4 prevented destruction of the alveoli—the small air sacs in lungs that are used to exchange gases, and in addition that it reduced the infiltration of a type of white blood cell called neutrophils, which is symptomatic of an inflammatory response, as well as levels of inflammatory cytokines and tissue-degrading enzymes.
In the exacerbation model, they found that the L4 administration prevented the influx of neutrophils. According to Taniguchi, “We found that L4 was as effective as dexamethasone in reducing neutrophil infiltration. This is very exciting, because dexamethasone, the treatment currently used for COPD, is a steroid medication that can have serious side effects and can in some cases make the outcome worse. It will be exciting if we can show that L4—a sugar molecule which we found had no adverse effects in the mice even at high doses—can be used as a treatment for this condition, which exerts a tremendous health burden.”