Really Off Target Effects In Arthritis Pain By Taking This Drug

Arthritis Pain, RA & OxyContin:

Arthritis pain is the most common cause of people visiting their healthcare providers. While an estimated 4 in 10 people in the USA suffer from this arthritis pain, only 1 in 4 of people taking painkillers achieve a full relief. This difference in the efficacy mostly does not come from one reason. Efficiency depends a lot on the genes and health conditions a person might have. In general, taking painkillers causes many — some very serious — side effects. The list of contraindications is usually quite long.

Is this painkiller okay to use for an Arthritis Pain Relief?

OxyContin → used mostly for strong and chronic pain, such as surgery, massive injury, longer-lasting strong pain or in terminal diseases. Its very highly addictive for patient with arthritis pain and RA.

According to NSAIDs countering inflammation:

Most of the research on arthritis pain and autoimmune, inflammatory diseases was done on rheumatoid arthritis (RA) , psoriasis and lupus as well. This drug reduce inflammation in the body. This, in theory could work well for people having an autoimmune diseases. But, reducing inflammation is not the only effect on the body.


How do this drug work for Arthritis Pain Relief?

This drug do not target one specific molecule or process in patient body. These are so called “off target” effects, with some of the effects being less than desirable for arthritis pain.

In their mechanism of action, they block the cyclooxygenases (COXs) enzyme family. The COX enzymes family has two enzymes: COX1 and COX2. COX1 promotes health of the stomach and intestine lining. COX 2 promotes inflammation, pain and fever.

Blocking COX1 causes the side effects, such as stomach ulcers, stroke, asthma, heart, liver and kidney problems. In addition, this drug prevents blood clotting, and wound healing, making the process of inflammation last longer.

Short-Term Use with Arthritis Pain Relief?

The problem of a leaky gut:

The organs of our digestive system are protected with a single layer of cells. The protective cell layer separates the inside of the abdomen from the contents of the gut (food, bacteria). This is very important, because the content of the gut can start or increase the inflammation in case if they leak from the gut into the abdomen. This is the starting point of an arthritis pain, where the immune system will get in contact with food particles and attack and destroy them, causing inflammation. This inflammation starts locally, but can spread fast throughout the entire body. At that point, the immune system will probably lose its oral tolerance too.

Side Effects of This Drug for Arthritis Pain Relief & RA as well!

  • abnormal skin sensations
  • chills
  • confusion
  • excessive yawning or sneezing
  • extreme drowsiness
  • diarrhea
  • mood changes
  • seizures (more serious)
  • sleep disturbance


Side Effects of This Drug for Arthritis Pain Relief & RA as well!

  • sweating
  • stomach pain
  • strong drug craving

American Autoimmune Related Diseases Association (AARDA) states:

“The National Institutes of Health (NIH) estimates up to 23.5 million Americans suffer from arthritis pain relief and that the prevalence is rising. We at AARDA say that 50 million Americans suffer from autoimmune disease…The NIH numbers only include 24 diseases for which good epidemiology studies were available. Researchers have identified 80-100 different autoimmune diseases and suspect at least 40 additional diseases of having an autoimmune basis. These diseases are chronic and can be life-threatening.”

Long-Term Use with Arthritis Pain Relief:

Arthritis pain is chronic by definition, meaning its symptoms progress over time and the underlying condition can be managed but not “cured.” The long-term nature of arthritis pain makes this drug addiction an even more likely risk than when these drugs are prescribed for short-term pain such as that following injury or surgery. Patients with arthritis pain  may have periods of remission or some alleviation of symptoms, but as a whole these disorders continue to develop much like addiction itself. Since pain increases in time and opiates decrease in effectiveness in time, when opiates are prescribed for autoimmune disorders, dosage can reach staggering and dangerous levels without an overall improvement in patient health. In fact long-term opiate use has just the opposite effect on mental and physical health. Source